Abstract:The high resistance of bacterial spores to physical treatments and chemical agents is a big problem in food industry. High pressure carbon dioxide (HPCD) processing cooperating with heat have a good effect of sterilization on bacterial spores. In additional, some additives can also promote its effect of sterilization and ensure its advantages such as sterilize at low temperature, maintains food quality effectively, easy to implementation and no-toxin residues. This paper presents a review focus on the relationship of structure and resistance, including elaborate on mechanism and influencing factors of HPCD sterilization technique.