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| Matrix Effects in the Determination of Sulfonamide Residues in Fish Meats by Ultra Performance Lliquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) |
| YAN Chun-rong;ZHANG Xiao-qiang;LIN Hui;XU Chun-xiang |
| Jiangsu Province Products Testing and Inspection Institute, Nanjing 210007, China |
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Abstract Extracts spiked with sulfonamide standards were used as samples for evaluating matrix effects in the
determination of veterinary sulfonamides residue in fish meats by ultra-high pressure liquid chromatography-tandem mass
spectrometry (LC-MS-MS) with respect to extraction solvents, clean-up methods, isotope internal standard and standard
calibration curve. Results suggested that the matrix interferences could be reduced by extraction with acetonitrile and cleanup
on an MCX cartridge or by liquid-liquid extraction and compensated by a calibration curve for spiked samples and
isotope internal standard.
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2013, Vol. 27 
