Matrix Effects in the Determination of Sulfonamide Residues in Fish Meats by Ultra Performance Lliquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS)
YAN Chun-rong;ZHANG Xiao-qiang;LIN Hui;XU Chun-xiang
Jiangsu Province Products Testing and Inspection Institute, Nanjing 210007, China
Abstract：Extracts spiked with sulfonamide standards were used as samples for evaluating matrix effects in the
determination of veterinary sulfonamides residue in fish meats by ultra-high pressure liquid chromatography-tandem mass
spectrometry (LC-MS-MS) with respect to extraction solvents, clean-up methods, isotope internal standard and standard
calibration curve. Results suggested that the matrix interferences could be reduced by extraction with acetonitrile and cleanup
on an MCX cartridge or by liquid-liquid extraction and compensated by a calibration curve for spiked samples and
isotope internal standard.
颜春荣；张晓强；林慧；徐春祥. 超高压液相色谱-串联质谱法(LC-MS-MS)测定鱼肉中磺胺类兽药残留的基质效应[J]. 肉类研究, 2013, 27(10): 17-20.
YAN Chun-rong;ZHANG Xiao-qiang;LIN Hui;XU Chun-xiang. Matrix Effects in the Determination of Sulfonamide Residues in Fish Meats by Ultra Performance Lliquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS). Meat Research, 2013, 27(10): 17-20.
2013, Vol. 27 
