Abstract:Abstract: Iron deficiency anemia is common in our country as nutritional deficiency disease and traditional iron supplementary has the problem of low absorptivity and high side effects. Heme iron is a kind of biological iron, which is compound of natural pigment and biological iron in animal blood, it is absorbed directly by intestinal mucosa and posseses high bioavailability, no side effects, it can be widely used as nutrition enhancer in chemistry, medicine and food industry. The function, application and preparation, purification of heme iron was reviewed in this article.