Abstract：An analytical method based on inductively coupled plasma mass spectrometry (ICP-MS) has been developed
for the simultaneous determination of 19 mineral elements (Mg, K, V, Cr, Mn, Fe, Ni, Cu, Zn, Ge, As, Se, Cd, Sn, Sb, Tb,
Hg, Pb and Bi) in seafood. After the samples were pretreated by microwave digestion with HNO3-H2O2, octopole collisionreaction
system (ORS) was used to eliminate the polyatomic interferences. Sc, Rh, In and Ir were used as internal standard
elements to compensate matrix effect and signal drift. The results indicated that the concentrations and responses of each
element showed a good linear relationship in the range of 0–50 mg/L with correlation coefficient no less than 0.9995. The
limits of detection (LOD) were in the range of 0.004–80.110 μg/L. The established method was validated by using it to
analyze the national standard reference materials of scallop (GBW10024), prawn (GBW10050) and oyster (GBW10068) and
it turned out that the relative standard deviation values of reproducibility (n = 6) were 0.8%–15.2%,and the analysis results
were all in the reference ranges.
